[Music Playing]
Male: Bottom line, we begin the age the moment we are born. How long the process takes and how well we do depends almost entirely upon how well we take care of our selves.
The human bodies are collection of cells, some estimate as many as a hundred trillion, but that is not the issue. The point is no serious discussion of ageing process can begin without first considering what is taking place at the molecular level as we grow older?
Male: Human cells will replicate somewhere between 40 to 80 times depending on the exact tissue. At that point, they simply stop in the sense they have aged and they just stop replicating that point.
What happens to those cells though is not like do they not continue to divide and make new cells. They also start changing the kind of proteins they make. A growing fiber blast makes collagen and related materials that provide the matrix that the cells grow on.
When a cell becomes senacyt, in other words it reaches its point of no longer being able to replicated, it now stops making collagen. It starts making enzymes and proteins that degrade the collagen and this matrix. That leads to disruption of the tissue.
Male: I think that the fundamental deficit in ageing is cell energy. I think ageing is primarily a mitochondria loss. The loss of their ability to burn energy, to maintain, to repair and your body function requires the ability to utilize oxygen and to dissipate oxygen.
Male: Obviously, oxygen is life sustaining but it has a downside and the downside is it causes destruction of many of the body’s molecules within the cells and limits the life span of cells and organs and tissues and increases the risk for disease and so forth.
Male: Modern theories of ageing generally fall in to two camps, damage theories and program theories.
Now, damage theories are primarily concern with the damages that occurs inside the cell over time.
Program theories sent around the idea that ageing results in large part from a sort of genetic clock that decides when cells can no longer operate and reproduce at a rate sufficient enough to maintain optimum health.
These distinctions are not necessarily mutually exclusive but they do serve as a useful guide for discussing current thinking on how and why we aged the way we do.
Male: So there is a constant battle on going on within the cell between the damage that occurs and the repair of that damage to return the cell to where it should be at homule status.
Female: You know through the normal process, these cells are ageing but they are replaced. If somehow, some of these just stay around, you actually shift the balance so that they are more dysfunctional cells in the tissue.
So I think both cell proliferation and cell disk and maintenance of cells who live throughout the life span of a tissue are three different aspects of ageing.
Male: When the causes of premature ageing in our society are bad dietary habits, use of alcohol, use of tobacco, obesity, not getting enough exercise and all of these are going to lead to deterioration of function before they would normally [Audio Cut]
Transcription by:
Scribe4you Transcription Services